Biggest Gainers on the NAS YTD 2025

December 14, 2025

Biggest Gainers

The biggest gainers in this list have seen their share price grow at a faster rate than the rest of the market so far this year. Stocks that are experiencing dramatic increases in share price can do so for a variety of reasons, including the sector they are in has turned (such as companies in the commodities space or a new sector that has huge future potential), the company is in talks to be taken over, or the company has restructured and earnings are turning better than expected.

NASDAQ

The National Association of Securities Dealers Automated Quotations (Nasdaq) located in New York City, is the most active stock exchange by volume in the United States.

About the Data

This table includes the top companies based on their percentage increase in share price year to date.

How do you use this table?

The biggest gainers are companies with upward momentum and potentially higher reward, but with increased risk. These stocks tend to have a higher trading volume and visibility in the marketplace. Stocks in this group can change direction quickly and tend to be short term trades. Stocks in this category are generally held for speculation or growth.

For an in-depth look at the fundamentals and valuation of each company, try the stockcalc platform free for 30 days.

SymbolNameTotal ReturnPeriod
RGC Regencell Bioscience Holdings Ltd 17653.04 YTD
DFDV DeFi Development Corp. 2424.62 YTD
NAKA Kindly MD, Inc. 1722.58 YTD
ASST Strive Asset Management 1329.15 YTD
TOI Oncology Institute Inc 932.36 YTD
SBET Sharplink Gaming Ltd 888.31 YTD
SVA Sinovac Biotech Ltd 850.08 YTD
NUTX Nutex Health Inc 429.06 YTD
TDUP ThredUp Inc 417.99 YTD
RGLS Regulus Therapeutics Inc 401.90 YTD
All data provided as at market close November 23, 2025.

Company Details

Regencell Bioscience Holdings Ltd

RGC:NAS

Total Return

17653.04

Period

YTD

Regencell Bioscience Holdings Limited operates as a Traditional Chinese medicine (TCM) bioscience company in Hong Kong. It focuses on the research, development, and commercialization of TCM for the treatment of neurocognitive disorders and degeneration, primarily for attention deficit hyperactivity disorder and autism spectrum disorder. The company was incorporated in 2014 and is headquartered in Causeway Bay, Hong Kong.

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DeFi Development Corp.

DFDV:NAS

Total Return

2424.62

Period

YTD

DeFi Development Corp. operates an online platform that provides data and software solutions that connect the commercial real estate industry to multifamily and commercial property professionals. The company offers Janover Pro, which provides an online matchmaking service where borrowers or brokers can get loans, and lenders can provide financing; Janover Connect, an investor portal; Janover Engage, a solution for the equity marketplace; and Janover AI, an artificial intelligence technology.

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Kindly MD, Inc.

NAKA:NAS

Total Return

1722.58

Period

YTD

Kindly MD, Inc., a healthcare and healthcare data company, provides direct health care services to patients integrating prescription medicine and behavioral health services. The company offers specialty outpatient clinical services based on a subscription and fee-for-service basis to augment traditional healthcare.

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Strive Asset Management

ASST:NAS

Total Return

1329.15

Period

YTD

Strive Asset Management, LLC is a privately owned investment manager. It primarily provides its services to investment companies. The firm is a large advisory firm, an investment adviser to an investment company which provides portfolio management for investment companies. The firm invests in exchange traded funds. The firm conducts in-house research to make its investments. Strive Asset Management, LLC was founded in 2022 and is based in Dallas, Texas.

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Oncology Institute Inc

TOI:NAS

Total Return

932.36

Period

YTD

The Oncology Institute, Inc., an oncology company, provides various medical oncology services in the United States. The company operates through three segments: Dispensary, Patient Services, and Clinical Trials & Other. It offers physician services, in-house infusion and dispensary, clinical trial, radiation, outpatient blood product transfusion, and patient support services, as well as educational seminars, support groups, counseling services, and 24/7 patient assistance services.

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SBET:NAS

Total Return

888.31

Period

YTD

SharpLink Gaming, Inc. engages in developing a treasury strategy centered on Ether. It operates in two segments, Affiliate Marketing and Ethereum Staking. The Affiliate Marketing segment provides performance-based customer acquisition services for sportsbooks and online casino gaming operators. It focuses on driving traffic and player acquisitions, retention, and conversions to regulated and global iGaming operator partners.

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Sinovac Biotech Ltd

SVA:NAS

Total Return

850.08

Period

YTD

Sinovac Biotech Ltd., a biopharmaceutical company, focuses in the research, development, manufacture, and commercialization of vaccines against human infectious diseases in the People's Republic of China. The company's product portfolio includes vaccines against hepatitis A and B; hand, foot, and mouth diseases caused by enterovirus 71 (EV71); seasonal influenza; H5N1 and H1N1 pandemic influenza; coronavirus; varicella; and mumps.

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Nutex Health Inc

NUTX:NAS

Total Return

429.06

Period

YTD

Nutex Health Inc. operates as a healthcare services and operations company in the United States. It operates through three segments: Hospital, Population Health Management (PHM), and Real Estate. The Hospital segment develops and operates a network of micro hospitals, specialty hospitals, and hospital outpatient departments that offer healthcare services, including emergency room care, inpatient care, and behavioural health.

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ThredUp Inc

TDUP:NAS

Total Return

417.99

Period

YTD

ThredUp Inc., together with its subsidiaries, operates an online resale platform in the United States. Its platform enables consumers to buy and sell primarily secondhand apparel, shoes, and accessories. ThredUp Inc. was incorporated in 2009 and is headquartered in Oakland, California.

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Regulus Therapeutics Inc

RGLS:NAS

Total Return

401.90

Period

YTD

Regulus Therapeutics Inc is a biotechnology company focused on the development of microRNA therapies. MicroRNA therapies target diseases such as cancer, metabolic diseases, fibrosis, and inflammatory diseases. The product candidate of the company is RGLS8429, an anti-miR next-generation oligonucleotide targeting miR-17 for the treatment of autosomal dominant polycystic kidney disease (ADPKD), and is in Phase 1b clinical development.

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Regencell Bioscience Hold and DeFi Development were the biggest gainers on the NAS YTD. See all the biggest gainers on the blog: https://www.stockcalc.com/Blog/biggest-gainers-nas-ytd-2025
Regencell Bioscience Hold $RGC and DeFi Development $DFDV were the biggest gainers on the #NAS YTD. See the full list of gainers: https://www.stockcalc.com/Blog/biggest-gainers-nas-ytd-2025
Regencell Bioscience Hold and DeFi Development were the biggest gainers on the NAS YTD. See all the biggest gainers on the blog: https://www.stockcalc.com/Blog/biggest-gainers-nas-ytd-2025

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